Kinetic recognition of AT-rich DNA by ruthenium complexes
Artikel i vetenskaplig tidskrift, 2007
(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
TRIS(PHENANTHROLINE)RUTHENIUM(II)
intercalation
STEREOSELECTIVITY
luminescence
ruthenium
MINOR-GROOVE
LIGANDS
BINDING
THREADING INTERCALATION
MODE
SPECIFICITY
DISSOCIATION
SEQUENCE
kinetics
DNA recognition
Författare
Pär Nordell
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Fredrik Westerlund
Chalmers University of Technology
Marcus Wilhelmsson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Bengt Nordén
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Per Lincoln
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 46 13 2203-2206Ämneskategorier (SSIF 2011)
Fysikalisk kemi
DOI
10.1002/anie.200604294