Kinetic recognition of AT-rich DNA by ruthenium complexes
Journal article, 2007
(Figure Presented) Finding AT tracts: High selectivity for long AT sequences can be attained through kinetically controlled DNA threading intercalation by binuclear ruthenium (II) complexes (see picture). The rate of intercalation is strongly correlated to the number of consecutive AT base pairs and is up to 2500-times higher with poly-(dAdT) 2 than with mixed-sequence DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
TRIS(PHENANTHROLINE)RUTHENIUM(II)
intercalation
STEREOSELECTIVITY
luminescence
ruthenium
MINOR-GROOVE
LIGANDS
BINDING
THREADING INTERCALATION
MODE
SPECIFICITY
DISSOCIATION
SEQUENCE
kinetics
DNA recognition
Author
Pär Nordell
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Fredrik Westerlund
Chalmers University of Technology
Marcus Wilhelmsson
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Bengt Nordén
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Per Lincoln
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 46 13 2203-2206Subject Categories (SSIF 2011)
Physical Chemistry
DOI
10.1002/anie.200604294