No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)
Artikel i vetenskaplig tidskrift, 2016
The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders.
Författare
Jan Jessen Krut
Göteborgs universitet
R.W. Price
University of California, San Francisco
Henrik Zetterberg
Göteborgs universitet
Dietmar Fuchs
Medizinische Universitat Innsbruck
Lars Hagberg
Göteborgs universitet
Aylin Yilmaz
Göteborgs universitet
Paola Cinque
IRCCS San Raffaele Scientific Institute
Staffan Nilsson
Göteborgs universitet
Chalmers, Matematiska vetenskaper, matematisk statistik
Magnus Gisslén
Göteborgs universitet
Virulence
2150-5594 (ISSN) 2150-5608 (eISSN)
Vol. 8 5 599-604Ämneskategorier (SSIF 2011)
Neurovetenskaper
DOI
10.1080/21505594.2016.1212155
PubMed
27435879