No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)
Journal article, 2016
The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders.
Author
Jan Jessen Krut
University of Gothenburg
R.W. Price
University of California, San Francisco
Henrik Zetterberg
University of Gothenburg
Dietmar Fuchs
Medizinische Universitat Innsbruck
Lars Hagberg
University of Gothenburg
Aylin Yilmaz
University of Gothenburg
Paola Cinque
IRCCS San Raffaele Scientific Institute
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Magnus Gisslén
University of Gothenburg
Virulence
2150-5594 (ISSN) 2150-5608 (eISSN)
Vol. 8 5 599-604Subject Categories (SSIF 2011)
Neurosciences
DOI
10.1080/21505594.2016.1212155
PubMed
27435879