Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature
Artikel i vetenskaplig tidskrift, 2015
The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.
Författare
Juliane Junesch
Chalmers, Teknisk fysik, Biologisk fysik
Gustav Emilsson
Chalmers, Teknisk fysik, Bionanofotonik
K. Xiong
Chalmers University of Technology
S. Kumar
University of Minnesota Twin Cities
T. Sannomiya
Tokyo Institute of Technology
Hudson Pace
Chalmers, Teknisk fysik, Biologisk fysik
J. Vörös
ETH Zurich
S. H. Oh
University of Minnesota Twin Cities
Marta Bally
Chalmers, Teknisk fysik, Biologisk fysik
Andreas Dahlin
Chalmers, Teknisk fysik, Biologisk fysik
Nanoscale
2040-3364 (ISSN)
Vol. 7 37 15080-15085Ämneskategorier (SSIF 2011)
Biokemi och molekylärbiologi
Kemiteknik
DOI
10.1039/c5nr04208a
PubMed
26351000