Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature
Journal article, 2015
The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.
Author
Juliane Junesch
Chalmers, Applied Physics, Biological Physics
Gustav Emilsson
Chalmers, Applied Physics, Bionanophotonics
K. Xiong
Chalmers University of Technology
S. Kumar
University of Minnesota Twin Cities
T. Sannomiya
Tokyo Institute of Technology
Hudson Pace
Chalmers, Applied Physics, Biological Physics
J. Vörös
ETH Zurich
S. H. Oh
University of Minnesota Twin Cities
Marta Bally
Chalmers, Applied Physics, Biological Physics
Andreas Dahlin
Chalmers, Applied Physics, Biological Physics
Nanoscale
2040-3364 (ISSN)
Vol. 7 37 15080-15085Subject Categories (SSIF 2011)
Biochemistry and Molecular Biology
Chemical Engineering
DOI
10.1039/c5nr04208a
PubMed
26351000