Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties
Artikel i vetenskaplig tidskrift, 2012
Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.
histology
modulus
dogs
tissue
surfaces
calcium phosphate
osseointegration
mechanical-properties
nanostructures
dental implants
biomechanics
mineral-content
topography
titanium
Författare
Ryo Jimbo
Malmo Hogskola
Paulo G Coelho
New York University
M. S. Bryington
Ohio State University
M. Baldassarri
New York University
N. Tovar
New York University
F Currie
Promimic AB
Mariko Hayashi
Malmo Hogskola
M. N. Janal
New York University
Martin Andersson
Chalmers, Kemi- och bioteknik, Teknisk ytkemi
Daisuke Ono
Nagasaki University
Stefan Vandeweghe
Universiteit Gent
Malmo Hogskola
Ann Wennerberg
Malmo Hogskola
Journal of Dental Research
0022-0345 (ISSN)
Vol. 91 12 1172-1177Ämneskategorier (SSIF 2011)
Odontologi
DOI
10.1177/0022034512463240