Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties
Journal article, 2012
Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.
histology
modulus
dogs
tissue
surfaces
calcium phosphate
osseointegration
mechanical-properties
nanostructures
dental implants
biomechanics
mineral-content
topography
titanium
Author
Ryo Jimbo
Malmo Hogskola
Paulo G Coelho
New York University
M. S. Bryington
Ohio State University
M. Baldassarri
New York University
N. Tovar
New York University
F Currie
Promimic AB
Mariko Hayashi
Malmo Hogskola
M. N. Janal
New York University
Martin Andersson
Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry
Daisuke Ono
Nagasaki University
Stefan Vandeweghe
Universiteit Gent
Malmo Hogskola
Ann Wennerberg
Malmo Hogskola
Journal of Dental Research
0022-0345 (ISSN)
Vol. 91 12 1172-1177Subject Categories (SSIF 2011)
Dentistry
DOI
10.1177/0022034512463240