Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid Bilayers.
Artikel i vetenskaplig tidskrift, 2012
A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains.
Författare
Marta Bally
Chalmers, Teknisk fysik, Biologisk fysik
Gustaf E Rydell
CNRS Centre National de la Recherche Scientifique
Raphael Zahn
ETH Zurich
Waqas Nasir
Göteborgs universitet
Christian Eggeling
Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute)
University of Oxford
Michael Breimer
Göteborgs universitet
Lennart Svensson
Linkopings universitet
Fredrik Höök
Chalmers, Teknisk fysik, Biologisk fysik
Göran Larson
Göteborgs universitet
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 51 48 12020-4Ämneskategorier (SSIF 2011)
Cell- och molekylärbiologi
Annan medicinsk grundvetenskap
Biofysik
Mikrobiologi inom det medicinska området
DOI
10.1002/anie.201205972
PubMed
23097253