Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid Bilayers.
Journal article, 2012
A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains.
Author
Marta Bally
Chalmers, Applied Physics, Biological Physics
Gustaf E Rydell
CNRS Centre National de la Recherche Scientifique
Raphael Zahn
ETH Zurich
Waqas Nasir
University of Gothenburg
Christian Eggeling
Max Planck Institute for Biophysical Chemistry (Karl Friedrich Bonhoeffer Institute)
University of Oxford
Michael Breimer
University of Gothenburg
Lennart Svensson
Linkopings universitet
Fredrik Höök
Chalmers, Applied Physics, Biological Physics
Göran Larson
University of Gothenburg
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 51 48 12020-4Subject Categories (SSIF 2011)
Cell and Molecular Biology
Other Basic Medicine
Biophysics
Microbiology in the medical area
DOI
10.1002/anie.201205972
PubMed
23097253