Robust Gain-Scheduled Controller Design for T1DM Individualised Model

Paper i proceeding, 2015

Novel original robust gain-scheduled controller design for individualized type 1 diabetes mellitus (T1DM) subject model is presented in this paper. For controller design an LPV model is created from insulin-glucose subsystem based on Bergman’s minimal model with subcutaneous insulin absorption and absorption of digested carbohydrates. Identification was performed on pharmacokinetics and pharmacodynamics characteristics of administered insulin and data collected from continuous glucose monitoring (CGM) system. The controller design approach guarantees the closed-loop stability and cost for all scheduled parameter changes. Simulation results show the benefits of the proposed approach.