Imaging mass spectrometry in neuroscience.
Artikel i vetenskaplig tidskrift, 2013
Imaging mass spectrometry is an emerging technique of great potential for investigating the chemical architecture in biological matrices. Although the potential for studying neurobiological systems is evident, the relevance of the technique for application in neuroscience is still in its infancy. In the present Review, a principal overview of the different approaches, including matrix assisted laser desorption ionization and secondary ion mass spectrometry, is provided with particular focus on their strengths and limitations for studying different neurochemical species in situ and in vitro. The potential of the various approaches is discussed based on both fundamental and biomedical neuroscience research. This Review aims to serve as a general guide to familiarize the neuroscience community and other biomedical researchers with the technique, highlighting its great potential and suitability for comprehensive and specific chemical imaging.
methods
Brain Chemistry
Mass
Secondary Ion
methods
Mass
methods
Humans
Neurotransmitter Agents
analysis
Animals
Mass Spectrometry
Spectrometry
Matrix-Assisted Laser Desorption-Ionization
Spectrometry
Författare
Jörg Hanrieder
Chalmers, Kemi- och bioteknik, Analytisk kemi
Nhu TN Phan
Göteborgs universitet
Michael Kurczy
Chalmers, Kemi- och bioteknik, Analytisk kemi
Andrew Ewing
Chalmers, Kemi- och bioteknik, Analytisk kemi
Göteborgs universitet
ACS Chemical Neuroscience
1948-7193 (ISSN)
Vol. 4 5 666-79Ämneskategorier (SSIF 2011)
Kemi
DOI
10.1021/cn400053c
PubMed
23530951