Aspergilli: Systems biology and industrial applications
Artikel i vetenskaplig tidskrift, 2012
Aspergilli are widely used as cell factories for the production of food ingredients, enzymes and antibiotics. Traditionally, improvement of these cell factories has been done using classical methods, that is, random mutagenesis and screening; however, advances in methods for performing directed genetic modifications has enabled the use of metabolic engineering strategies. Genome sequencing of Aspergilli was originally trailing behind developments in the field of bacteria and yeasts, but with the recent availability of genome sequences for several industrially relevant Aspergilli, it has become possible to implement systems biology tools to advance metabolic engineering. These tools include genome-wide transcription analysis and genome-scale metabolic models. Herein, we review achievements in the field and highlight the impact of Aspergillus systems biology on industrial biotechnology.
steady-state
proteomics
modeling approach
fluxes
carbohydrate-metabolism
niger
Industrial biotechnology
Metabolic engineering
nidulans
metabolic control analysis
genome
Aspergillus
Systems biology
citric-acid accumulation
Författare
Christoph Knuf
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Jens B Nielsen
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Biotechnology journal
1860-6768 (ISSN) 1860-7314 (eISSN)
Vol. 7 9 1147-1155Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)
Europeiska kommissionen (FP7) (EC/FP7/247013), 2010-01-01 -- 2014-12-31.
Ämneskategorier (SSIF 2011)
Biologiska vetenskaper
Styrkeområden
Energi
Livsvetenskaper och teknik (2010-2018)
DOI
10.1002/biot.201200169