Modulation and binding properties of extended glycoluril molecular clips

Journal article, 2008

A glycoluril clip (1) provides a deep cavity for binding of guest molecules. Guest species interact preferentially via hydrogen bonding or ion–lone pair interactions. Complexation-induced conformational modulation of the cavity wall distance was observed. At higher guest–host ratios, inclusion compounds with organic guest molecules are obtained. The X-ray crystallographic structure of 1.(NH4PF6).3CHCl3.2CH3OH shows formation of a network of clips connected via polar and non-polar interactions.