Investigation of genes coding for inflammatory components in Parkinson's disease.
Journal article, 2005
Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles. The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.
metabolism
Polymorphism
Tumor Necrosis Factor-alpha
Alleles
Inflammation
metabolism
metabolism
1-Alkyl-2-acetylglycerophosphocholine Esterase
genetics
Genetic
genetics
Interferon
Chemokine CCL2
Interferon Type II
Humans
genetics
Promoter Regions (Genetics)
genetics
Age Factors
genetics
genetics
Interleukin-10
genetics
Intercellular Adhesion Molecule-1
Parkinson Disease
Middle Aged
Brain
genetics
genetics
metabolism
metabolism
genetics
Genotype
DNA Primers
Receptors
metabolism
metabolism
complications
metabolism
metabolism
genetics
metabolism
complications
genetics
Author
Anna Håkansson
University of Gothenburg
Lars Westberg
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Silvia Buervenich
Karolinska Institutet
A Carmine
Karolinska Institutet
Björn Holmberg
University of Gothenburg
O Sydow
Karolinska Institutet
L Olson
Karolinska Institutet
Bo Johnels
University of Gothenburg
Elias Eriksson
University of Gothenburg
Hans Nissbrandt
University of Gothenburg
Movement Disorders
0885-3185 (ISSN) 1531-8257 (eISSN)
Vol. 20 5 569-73Subject Categories (SSIF 2011)
MEDICAL AND HEALTH SCIENCES
DOI
10.1002/mds.20378
PubMed
15648059