Association between the estrogen receptor beta gene and age of onset of Parkinson's disease.
Journal article, 2004
The purpose of this study was to investigate the potential contribution of genetic variants in the estrogen receptor beta gene to the aetiology of Parkinson's disease (PD). Several lines of evidence from human and animal studies suggest a protective role for estrogen in PD. Recently the estrogen receptor beta subtype was reported to be an important mediator of estrogen actions in the nigrostriatal dopamine system. Two single nucleotide polymorphisms at position 1730 and 1082 in the ER beta gene were genotyped, using pyrosequencing, in 260 patients with PD and 308 controls recruited from the Swedish population. Neither of the two estrogen receptor beta polymorphisms was associated with an increased risk for PD. However, the G allele of the A1730G polymorphism was more frequent in patients with an early age of onset than in patients with a late age of onset of PD (P = 0.006). Patients carrying the GG genotype had an odds ratio of 2.2 for having an early onset of PD compared to non-carriers. In conclusion, our results indicate that genetic variation in the estrogen receptor beta gene may influence the age of onset of PD.
Humans
Gene Frequency
Estrogen Receptor beta
Aged
genetics
Pair 14
genetics
Receptors
genetics
Human
epidemiology
Odds Ratio
Estrogen
Polymorphism
Chromosomes
Genetic Predisposition to Disease
epidemiology
Female
Middle Aged
genetics
Male
Sweden
Adult
Parkinson Disease
Case-Control Studies
Age of Onset
Chi-Square Distribution
Single Nucleotide
Author
Lars Westberg
University of Gothenburg
Anna Håkansson
University of Gothenburg
Jonas Melke
University of Gothenburg
Haydeh Niazi Shahabi
University of Gothenburg
Staffan Nilsson
Chalmers, Department of Mathematical Statistics
University of Gothenburg
S Buervenich
Karolinska Institutet
A Carmine
Karolinska Institutet
Jarl Ahlberg
University of Gothenburg
M B Grundell
Slottskogens Care Centre
B Schulhof
Slottskogens Care Centre
K Klingborg
Slottskogens Care Centre
Björn Holmberg
University of Gothenburg
O Sydow
Karolinska Institutet
L Olson
Karolinska Institutet
Bo Johnels
University of Gothenburg
Elias Eriksson
University of Gothenburg
Hans Nissbrandt
University of Gothenburg
Psychoneuroendocrinology
0306-4530 (ISSN)
Vol. 29 8 993-8Subject Categories (SSIF 2011)
MEDICAL AND HEALTH SCIENCES
DOI
10.1016/j.psyneuen.2003.08.010
PubMed
15219649