Systems Biology of Metabolism
Book chapter, 2017
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.
Saccharomyces-Cerevisiae
Reconstruction proteomics
Reductive Glutamine-Metabolism
systems
In-Vivo Analysis
Genome-Scale Models
genome-scale metabolic models
Gut Microbiota
Global
metabolomics
Mitochondrial Pyruvate Carrier
metabolic engineering
Gene-Expression
Escherichia-Coli
Flux Analysis
Author
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Annual Review of Biochemistry
0066-4154 (ISSN) 1545-4509 (eISSN)
Vol. 86 245-275978-0-8243-0886-5 (ISBN)
Subject Categories (SSIF 2011)
Bioinformatics and Systems Biology
DOI
10.1146/annurev-biochem-061516-044757
ISBN
978-0-8243-0886-5