High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones
Journal article, 2017
Polyelectrolyte-coated nanoparticles consisting of terbium and gadolinium complexes with calix[ 4] arene tetra-diketone ligand were first synthesized. The antenna effect of the ligand on Tb(III) green luminescence and the presence of water molecules in the coordination sphere of Gd(III) bring strong luminescent and magnetic performance to the core-shell nanoparticles. The size and the core-shell morphology of the colloids were studied using transmission electron microscopy and dynamic light scattering. The correlation between photophysical and magnetic properties of the nanoparticles and their core composition was highlighted. The core composition was optimized for the longitudinal relaxivity to be greater than that of the commercial magnetic resonance imaging (MRI) contrast agents together with high level of Tb(III)-centered luminescence. The tuning of both magnetic and luminescent output of nanoparticles is obtained via the simple variation of lanthanide chelates concentrations in the initial synthetic solution. The exposure of the pheochromocytoma 12 (PC 12) tumor cells and periphery human blood lymphocytes to nanoparticles results in negligible effect on cell viability, decreased platelet aggregation and bright coloring, indicating the nanoparticles as promising candidates for dual magneto-fluorescent bioimaging.
Author
R. Zairov
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Kazan Federal University
A. Mustafina
Kazan Federal University
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
N. Shamsutdinova
Kazan Federal University
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
I. Nizameev
Kazan National Research Technological University
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
Beatriz Moreira
University of Gothenburg
S. Sudakova
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
S. Podyachev
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
A. Fattakhova
Kazan Federal University
Gulnara Safina
University of Gothenburg
Chalmers, Physics, Biological Physics
I. Lundstrom
Lulea tekniska Universitet
Linkopings universitet
A. Gubaidullin
A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
A. Vomiero
Lulea tekniska Universitet
Scientific Reports
2045-2322 (ISSN)
Vol. 7 40486Roots
Basic sciences
Subject Categories (SSIF 2011)
Chemical Engineering
DOI
10.1038/srep40486