Heme metabolism in stress regulation and protein production: From Cinderella to a key player.
Journal article, 2016
Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.
Saccharomyces cerevisiae
metabolism
Animals
metabolism
Heme
metabolism
Saccharomyces cerevisiae Proteins
Plants
Archaea
biosynthesis
metabolism
Author
Jose Luis Martinez Ruiz
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Dina Petranovic Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Bioengineered Bugs
2165-5979 (ISSN) 2165-5987 (eISSN)
Vol. 7 2 112-5Subject Categories (SSIF 2011)
Industrial Biotechnology
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1080/21655979.2015.1126016
PubMed
26731643