Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
Paper in proceeding, 2014
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
Author
Murillo L. Martins
Niels Bohr Institute
UNESP-Universidade Estadual Paulista
A. Orecchini
Universita degli Studi di Perugia
Institut Laue-Langevin
Luis Aguilera Medina
Chalmers, Applied Physics, Condensed Matter Physics
Juergen Eckert
University of South Florida Tampa
J.P. Embs
Paul Scherrer Institut
Aleksandar Matic
Chalmers, Applied Physics, Condensed Matter Physics
M.J. Saeki
UNESP-Universidade Estadual Paulista
Heloisa N. Bordallo
Niels Bohr Institute
EPJ Web of Conferences
21016275 (ISSN) 2100014X (eISSN)
Vol. 83 Art. no. 02011- 02011Subject Categories (SSIF 2011)
Condensed Matter Physics
DOI
10.1051/epjconf/20158302011