Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
Journal article, 2014
Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a major challenge due to strong linkage disequilibrium and an overall high physical density of candidate variants. We aimed to refine the MHC association in a geographically restricted PSC patient panel.
Author
Sigrid Næss
Oslo University Hospital
Universitetet i Oslo
Benedicte A Lie
Oslo University Hospital
Espen Melum
Oslo University Hospital
Marita Olsson
Chalmers, Mathematical Sciences, Mathematical Statistics
University of Gothenburg
Johannes R Hov
Oslo University Hospital
Universitetet i Oslo
Peter J P Croucher
UC Berkeley
Jochen Hampe
Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
Erik Thorsby
Universitetet i Oslo
Oslo University Hospital
Annika Bergquist
Karolinska University Hospital
James A Traherne
Cambridge Institute for Medical Research
University of Cambridge
Erik Schrumpf
Oslo University Hospital
Kirsten Muri Boberg
Universitetet i Oslo
Oslo University Hospital
Stefan Schreiber
Christian-Albrechts-Universitat zu Kiel
Andre Franke
Christian-Albrechts-Universitat zu Kiel
Tom H Karlsen
Oslo University Hospital
Universitetet i Oslo
PLoS ONE
1932-6203 (ISSN)
Vol. 9 12 e114486- e114486Subject Categories (SSIF 2011)
Biological Sciences
Genetics
Areas of Advance
Life Science Engineering (2010-2018)
DOI
10.1371/journal.pone.0114486
PubMed
25521205