Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity
Journal article, 2014
The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH(3)) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L-1)](ttcH(2))(ClO4)center dot EtOH center dot H2O (1), where L-1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
crystal structure
acetylcholinesterase activity
complexes
trimercaptotriazine
trithiocyanuric acid
Schiff base
Author
Pavel Kopel
Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut
Mendelova univerzita v Brne
Karel Dolezal
Univerzita Palackého v Olomouci
Vratislav Langer
Chalmers, Chemical and Biological Engineering, Environmental Inorganic Chemistry
D. Jun
Faculty Hospital at Hradec Kralove
Univerzita obrany v Brne
V. Adam
Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut
Mendelova univerzita v Brne
K. Kuca
Faculty Hospital at Hradec Kralove
R. Kizek
Mendelova univerzita v Brne
Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut
Molecules
1420-3049 (ISSN)
Vol. 19 4 4338-4354Subject Categories (SSIF 2011)
Inorganic Chemistry
DOI
10.3390/molecules19044338