Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands
Journal article, 2011
Methods to produce a range of new phosphine-diamine ligands from phosphino-aldehydes have been developed and a hypothesis that larger P-substituents would increase the enantioselectivity towards the (S) isomer in Ru-catalysed ketone hydrogenation of acetophenone has been examined; the successful validation of this hypothesis is further evidence that the mechanism of these catalysts involves a secondary amine assisted reduction.
imines
aromatic ketones
alkylation
asymmetric hydrogenation
ruthenium hydride complexes
design
hybrid ligands
aminophosphine ligands
proline
rhodium
Author
S. D. Phillips
University of St Andrews
Kristian Andersson
Chalmers, Chemical and Biological Engineering, Organic Chemistry
Nina Kann
Chalmers, Chemical and Biological Engineering, Organic Chemistry
M. T. Kuntz
Washington and Lee University
M. B. France
Washington and Lee University
P. Wawrzyniak
University of St Andrews
M. L. Clarke
University of St Andrews
Catalysis Science and Technology
2044-4753 (ISSN) 2044-4761 (eISSN)
Vol. 1 8 1336-1339Subject Categories (SSIF 2011)
Chemical Sciences
DOI
10.1039/c1cy00253h