HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.
Journal article, 2010
Occasional cases of viral escape in cerebrospinal fluid (CSF) despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been reported. We investigated CSF viral escape in subjects treated with commonly used antiretroviral therapy regimens in relation to intrathecal immune activation and central nervous system penetration effectiveness (CPE) rank.
Female
Treatment Outcome
HIV Infections
Reverse Transcriptase Polymerase Chain Reaction
isolation & purification
isolation & purification
Male
Anti-HIV Agents
virology
Cerebrospinal Fluid
Cross-Sectional Studies
Viral Load
Plasma
virology
analysis
Viral
Blood-Brain Barrier
Middle Aged
Neopterin
drug therapy
Enzyme-Linked Immunosorbent Assay
virology
RNA
Humans
HIV-1
Author
Arvid Edén
University of Gothenburg
Dietmar Fuchs
Medizinische Universitat Innsbruck
Lars Hagberg
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Serena Spudich
University of California, San Francisco
Bo Svennerholm
University of Gothenburg
R.W. Price
University of California, San Francisco
Magnus Gisslén
University of Gothenburg
Journal of Infectious Diseases
0022-1899 (ISSN) 1537-6613 (eISSN)
Vol. 202 12 1819-25Subject Categories (SSIF 2011)
Infectious Medicine
DOI
10.1086/657342
PubMed
21050119