Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide
Journal article, 2010
A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.
in-vivo
interference
delivery
mechanism
emulsions
microspheres
sirna
rna
Author
J. Ge
Stanford University
G. B. Jacobson
Stanford University
Tatsiana Lobovkina
Stanford University
Krister Holmberg
Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry
R. N. Zare
Stanford University
Chemical Communications
1359-7345 (ISSN)
Vol. 46 47 9034-9036Subject Categories (SSIF 2011)
Chemical Sciences
DOI
10.1039/c0cc04258g