A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging
Journal article, 2010
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (C) 2010 Elsevier B.V. All rights reserved.
MRI
poly(ethylene oxide)
Dissolution
diffusion
ALE
rubbery
hpmc matrices
glassy-polymers
drug-delivery
release
mathematical-models
Mathematical modelling
reptation
erosion
Polyethylene oxide
Author
E. Kaunisto
Lunds Universitet
Susanna Abrahmsén-Alami
AstraZeneca Sweden
P. Borgquist
Gambro AB
Anette Larsson
SuMo Biomaterials
Chalmers, Chemical and Biological Engineering, Pharmaceutical Technology
B. Nilsson
Lunds Universitet
A. Axelsson
Lunds Universitet
Journal of Controlled Release
0168-3659 (ISSN)
Vol. 147 2 232-241Subject Categories (SSIF 2011)
Chemical Sciences
DOI
10.1016/j.jconrel.2010.07.102