Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran
Journal article, 2010
A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.
light-activation
DNA recognition
DNA-binding
photochromism
molecular logic
Author
Martin Hammarson
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Johanna Andersson
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Shiming Li
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Per Lincoln
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Joakim Andreasson
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Chemical Communications
1359-7345 (ISSN)
Vol. 46 38 7130-7132Photochromic Systems for Solid State Molecular Electronic Devices and Light-Activated Cancer Drugs (PHOTOCHROMES)
European Commission (FP7) (203952), 2008-09-01 -- 2013-08-31.
Subject Categories (SSIF 2011)
Physical Chemistry
DOI
10.1039/c0cc01682a