Transition-Metal-Catalyzed Propargylic Substitution
Journal article, 2009
(Chemical Equation Presented) Keen for a share in the glory: Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper-catalyzed asymmetric propargylic amination reactions. Nu = nucleophile © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
propargylic
nucleophilic substitution
acetates
alkynes
enoxysilanes
alkylation
substitution
asymmetric catalysis
amines
transition metals
esters
alcohols
complexes
amination
acetone
nucleophilic-substitution
Author
N. Ljungdahl
Chalmers University of Technology
Nina Kann
Chalmers, Chemical and Biological Engineering, Organic Chemistry
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 48 4 642-644Subject Categories (SSIF 2011)
Physical Chemistry
Chemical Sciences
DOI
10.1002/anie.200804114