Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates
Journal article, 2009
Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.
nmr
molecular
complexes
junction
recognition
supramolecular cylinder
nucleic-acids
linear dichroism spectroscopy
Author
Y. Parajo
Chalmers University of Technology
J. Malina
The University of Warwick
I. Meistermann
The University of Warwick
G. J. Clarkson
The University of Warwick
M. Pascu
The University of Warwick
University of Birmingham
A. Rodger
The University of Warwick
M. J. Hannon
University of Birmingham
The University of Warwick
Per Lincoln
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Dalton Transactions
1477-9226 (ISSN) 1477-9234 (eISSN)
25 4868-4874Subject Categories (SSIF 2011)
Physical Chemistry
Chemical Sciences
DOI
10.1039/b822039e