Internal standard in surface-enhanced Raman spectroscopy
Journal article, 2004
A method is presented for the use of SAM layers as internal standards for calibration in surface-enhanced Raman spectroscopy. Three cyano-containing compounds were attached to gold colloids via a metal-sulfur bond and evaluated for spectral stability and normalization capacity. The results show that the analyte, rhodamine 6G, and the internal standard signal enhancement covaried, and it was possible to quantify the analyte with PLS. The fact that the enhancing substrate was chaotic assemblies with large variation in signal enhancement shows the versatility of this method.
chemical imaging
gold nanoparticles
surface enhanced Raman spectroscopy
self-assembled monolayer
multivariate analysis
PCA
SAM
SERS
internal standard
principal components analysis
PLS
Author
Anders Lorén
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Johan Engelbrektsson
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Charlotte Eliasson
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Mats Josefson
AstraZeneca Sweden
Chalmers University of Technology
Jonas Abrahamsson
University of Gothenburg
Magnus Johansson
Chalmers, Department of Chemistry and Bioscience, Organic Chemistry
Katarina Abrahamsson
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
Analytical Chemistry
0003-2700 (ISSN) 1520-6882 (eISSN)
Vol. 76 24 7391-7395Subject Categories (SSIF 2011)
Analytical Chemistry
Chemical Sciences
DOI
10.1021/ac0491298